The earliest string model, the bosonic string, incorporated only bosons, although this view developed to the superstring theory, which posits that a connection (a "supersymmetry") exists between bosons and fermions. String theories also require the existence of several extra dimensions to the universe that have been compactified into extremely small scales, in addition to the four known spacetime dimensions.
The theory has its origins in an effort to understand the strong force, the dual resonance model (1969). Subsequent to this, five superstring theories were developed that incorporated fermions and possessed other properties necessary for a theory of everything. Since the mid-1990s, in particular due to insights from dualities shown to relate the five theories, an eleven-dimensional theory called M-theory is believed to encompass all of the previously distinct superstring theories.
Many theoretical physicists (among them Stephen Hawking, Edward Witten, Juan Maldacena and Leonard Susskind) believe that string theory is a step towards the correct fundamental description of nature. This is because string theory allows for the consistent combination of quantum field theory and general relativity, agrees with general insights in quantum gravity (such as the holographic principle and black hole thermodynamics), and because it has passed many non-trivial checks of its internal consistency. According to Hawking in particular, "M-theory is the only candidate for a complete theory of the universe." Nevertheless, other physicists, such as Richard Feynman and Glashow, have criticized string theory for not providing novel experimental predictions at accessible energy scales.
In the context of the show, Sheldon and Amy have published a paper on Super-Asymmetry which though is not accepted in the real world may get them a Nobel Prize in The Big Bang Theory.