Mrs. Cooper was the mother of George Cooper Sr.. His name is seen on the family tree on Sheldon's board in "The Cruciferous Vegetable Amplification".
She and her husband are deceased as seen on Sheldon's whiteboard.
- Husband: Mr. Cooper
- Son: George Cooper Sr.
- Daughter: Unnamed
- Daughter-in-law: Mary Cooper
- Son-in-law: Unnamed
- Grandsons: Sheldon Cooper, George Cooper Jr.
- Granddaughter: Missy Cooper
- Great-Grandson: Unnamed
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