They are first mentioned in "The Celebration Reverberation" when Leonard says that if the Christmas card has a picture of his wife and his kids and his dogs and his horses all in matching pajamas, he begs Penny to burn the letter.
- Father: Michael Hofstadter
- Mother: Unnamed
- Uncles: Leonard Hofstadter, Unnamed
- Aunts: Unnamed, Penny
- Cousins once removed: Unnamed
- Grandfather: Alfred Hofstadter
- Grandmother: Beverly Hofstadter
- Great-grandfather: Unnamed
- Great-grandmother: Unnamed
- Great-uncles: Floyd, Unnamed
- Great-aunts: Edna, Nancy, Unnamed
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