- Nintendo Wii
- Noah Webster
- Nobel Prize
- Non-clerical professionals
- Nora
- Nursis Manookian
- OCD Exercises
- Officer Hernandez
- Oliver (Season 11)
- Oliver Lorvis
- Om Prakash
- One Bad Night and Chaos of Selfish Desires
- Oscar
- Outside References to The Big Bang Theory
- Owen Thayer
- PMS
- Paige Swanson
- Paintball
- Painting of Penny and Amy
- Pamela Adlon
- Pancake Sunday and Textbook Flirting
- Paradoxical Moment-of-Inertia Changes Due to Putative Super-Solids
- Pasadena
- Pasadena (City)
- Pasadena (Episode)
- Pasha D. Lychnikoff
- Passion's Harvest and a Sheldocracy
- Pastor Andy
- Pastor Charlie
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- Pastor Rob
- Pastor Steve
- Pat
- Pat's Firehouse
- Patricia
- Paul Yen
- Pauline
- Peg
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- Penny's Cousin
- Penny's Family
- Penny's Family Cat
- Penny's Family Home
- Penny's Friends
- Penny's Maternal Grandfather
- Penny's Maternal Grandmother
- Penny's Nephew
- Penny's Paternal Grandfather
- Penny's Paternal Grandmother
- Penny's Posse
- Penny's Posse/Gallery
- Penny's Serial Ape-ist Fan Boys
- Penny's Uncle
- Penny's Wardrobe
- Penny/Gallery
- Penny/Gallery - Female Friends
- Penny/Gallery - Groups
- Penny/Gallery - Herself
- Penny/Gallery - Leonard
- Penny/Gallery - Male Friends
- Penny/Gallery - Penny's Posse
- Penny/Gallery - Sheldon
- Penny Blossoms
- Pepper
- Peter Chakos
- Peter Pan
- Photomultiplier
- Phyllis
- Physical cosmology
- Physicists Gone Wild
- Pictionary
- Pilot
- Pilot (Young Sheldon)
- Pina Pete's
- Piney Woods Hotel & Spa
- Pish Posh and a Secret Back Room
- PlayStation 3
- Plimpton
- Plot Holes
- Poker, Faith, and Eggs
- Police/Guards
- Pongo Pygmaeus and a Culture that Encourages Spitting
- Pop-Pop
- Potato Salad, a Broomstick, and Dad's Whiskey
- Potential Energy and Hooch on a Park Bench
- President Siebert
- Princeton University
- Princeton University waitress
- Priya's Husband
- Priya Koothrappali
- Professor Boucher
- Professor Crawley
- Professor Finkleday
- Professor Goldfarb
- Professor Laughlin
- Professor Proton
- Professor Salzman
- Professor Sharp
- Professor Tupperman
- Professor Willard
- Professors/Academics
- Psychiatrist
- Quantum mechanics
- Quirky Eggheads and Texas Snow Globes
- Rabbi Schneiderman
- Rachel Bay Jones
- Raegan Revord
- Raj's New Apartment
- Raj's Wardrobe
- Raj's apartment
- Raj's unnamed siblings
- Raj and Anu
- Raj and Claire
- Raj and Emily
- Rajesh Koothrappali
- Rajesh Koothrappali/Gallery
- Rajesh Koothrappali/Gallery - Female Friends
- Rajesh Koothrappali/Gallery - Groups
- Rajesh Koothrappali/Gallery - Himself
- Rajesh Koothrappali/Gallery - Howard
- Rajesh Koothrappali/Gallery - Male Friends
- Rajesh and Priya's Three Unnamed Sisters-in-law And One Unnamed Brother-in-law
- Ralph
- Ramona Nowitzki
- Randall
- Reagan To
- Reba McEntire
- Rebecca
- Reed
- Regina King
- Rene Descartes
- Rent
- Research Lab
- Rex Linn
- Rhonda
- Richard
- Richard Feynman
- Richard Rosenstock
- Richard Williams
- Ricky (The Big Bang Theory)
- Ricky (Young Sheldon)
- Riki Lindhome
- Rob Cavallo
- Robb Rothman
- Robert (Young Sheldon)
- Robert Clotworthy
- Robert Cohen
- Robert Downey Jr.
- Robert Wolcott
- Robert Wu
- Robin (Young Sheldon)
- Robin Difford
- Robin Hood
- Rock, Paper, Scissors, Lizard, Spock
- Rock Band Night
- Rockets, Communists, and the Dewey Decimal System
- Rodriguez
- Roger Abbott
- Ron
- Ronald Hodges
- Rostenkowski
- Rottweiler
- Roy
- Ruchi
- Running Gags
- Russian
- Ruth Cooper
- Ruthless, Toothless and a Week of Bed Rest
- Ryan Phuong
- Salsa Dancing
- Sam
- Sam (Young Sheldon)
- Sam Kass
- Sam Seder
- Sam Wolowitz
- Sanjay (Raj's cousin)
- Santa
- Sara Gilbert
- Sara Rue
- Sarah
- Sarah (Season 3)
- Sarah Baker
- Sarah Michelle Gellar
- Scanners
- Schedule
- Schrödinger's Cat
- Scott
- Scott Kapinski
- Season 1
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- Season 3
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- Season 4
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- Season 6
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- Season 7
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- Season 8
- Season 9
- Sebastian
- Secret Agent Laser Obstacle Chess
- Selective mutism
- Selena
- Serial Ape-ist
- Serial Ape-ist 2: Monkey See, Monkey Kill
- Seven Deadly Sins and a Small Carl Sagan
- Shannon
- Shannon Dixon
- She Blinded Me with Science
- Sheldon's Bar Women
- Sheldon's Bedroom
- Sheldon's Birthday Party
- Sheldon's Cats
- Sheldon's Knock
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- Sheldon's Spot
- Sheldon's Vacation Photos
- Sheldon's Wardrobe
- Sheldon Cooper
- Sheldon Cooper's Council of Ladies
- Sheldon Cooper's Science Center
- Sheldon Cooper/Gallery
- Sheldon Cooper/Gallery - Amy
- Sheldon Cooper/Gallery - Family
- Sheldon Cooper/Gallery - Female Friends
- Sheldon Cooper/Gallery - Groups
- Sheldon Cooper/Gallery - Himself
- Sheldon Cooper/Gallery - Leonard
- Sheldon Cooper/Gallery - Male Friends
- Sheldon Cooper/Gallery - Penny
- Sheldon Cooper Presents: Fun with Flags
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