"Little House on the Prairie" is one of Amy Farrah Fowler's favorite childhood television shows.
In "The Raiders Minimization", Sheldon makes an unscheduled Skype call to Amy to make a spontaneous dating|date to watch "Little House on the Prairie" as a ruse. On the date, Amy explains how much she enjoys it that she wanted to like on a farm. She once tried to milk her cat who gave her a tangy bowl of Cheerios.
The family in the opening scene was squatting in a cabin on native land. Sheldon says what the Americans did to the Native Indians was wrong.
Laura was eating a peanut butter sandwich. He points out that peanut butter wasn't invented until the early 1900s.
Amy catches on quickly that he's trying to get back at her for ruining "Raiders of the Lost Ark".
Sheldon also notices Dr. Baker was using a telephone in the country even though they were only available in large cities at the time. He calls it the "Little House on the Preposterous". Amy then tells him that since she is his girlfriend, he only has to tell her when he is mad and not seek revenge.
In "The Troll Manifestation", Bernadette tells Penny that Amy likes to write LHOTP fan fiction. The story read by the girls had other characters in it in a similar setting. Amy was Amelia and Sheldon was a time travelling visitor from the future.
In "The Celebration Reverberation", Sheldon prepares Amy a frontier birthday dinner LHOTP style which excites Amy; however, they both gets food poisoning.