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Gretchen is a friend or former friend of Penny.

She is only seen in "The Tangible Affection Proof", where she and her boyfriend who is an ex-boyfriend of Penny's who had cheated on Penny with Gretchen are having a Valentine's Day dinner at the same restaurant Penny, Leonard, Howard and Bernadette are having their double date Valentine's Day dinner.

Gretchen's boyfriend then asks her to marry him in the restaurant and she says 'yes' and they kiss, getting applause from the other restaurant guests.

Gretchen is portrayed by Briana Cuoco, sister of Kaley Cuoco.