Edna is an aunt of Leonard Hofstadter, Michael Hofstadter and their sister.
- Brother or ex-brother-in-law: Alfred Hofstadter
- Sister or ex-sister-in-law: Beverly Hofstadter
- Nephews: Leonard Hofstadter, Michael Hofstadter
- Niece: Unnamed
- Niece-in-Laws: Penny Hofstadter née ?, Unnamed (via Michael)
- Nephew-in-Law: Unnamed
- Unnamed great-nephews/great-nieces (via Michael)
- Possible Father: Unnamed
- Possible Mother: Unnamed
- Possible Brother/Husband: Floyd
- Possible Sisters: Nancy, Unnamed
- Possible Children: Unnamed
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