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Denise is the assistant manager of Stuart's comic book store.

After his store becomes very popular, Stuart hires Denise who is very into comics and very perspective. At first, Sheldon doesn't like the change, but starts to like her because of her comic book knowledge and that she figures out his preferences in comic books. After annoying Amy when Sheldon keeps talking about her at dinner, Amy goes down and demands that Denise teach her enough about comics to make it appear that she likes them.

In "The Bow Tie Asymmetry", Stuart asks her to come to Sheldon and Amy's Wedding with him. Denise declines until she learns that Mark Hamill is going to be there. And Stuart has to buy her a dress. She sits besides Stuart and watches as he answers questions about Star Wars better than Star Wars actor Mark Hamill. Denise is amazed by his knowledge and calls him hot.

A new relationship started between Denise and Stuart in the second episode of season 12, "The Wedding Gift Wormhole".

Appearances

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The Big Bang Theory Characters, Cast & Crew
Characters Main Leonard Hofstadter  ‧  Sheldon Cooper  ‧  Penny Hofstadter  ‧  Howard Wolowitz  ‧  Rajesh Koothrappali  ‧  Amy Farrah Fowler  ‧  Bernadette Rostenkowski-Wolowitz  ‧  Stuart Bloom  ‧  Emily Sweeney   ‧  Leslie Winkle    The Social Group
Recurring/Minor Debbie Wolowitz  ‧  Barry Kripke  ‧  Priya Koothrappali  ‧  Dr. V. M. Koothrappali  ‧  Mrs. Koothrappali  ‧  Stephanie Barnett  ‧  Lucy  ‧  Mary Cooper  ‧  Zack Johnson  ‧  Beverly Hofstadter  ‧  Mike Rostenkowski  ‧  Alex Jensen  ‧  Professor Proton  ‧  Missy Cooper  ‧  Ramona Nowitzki  ‧  Dan  ‧  Josh Wolowitz  ‧  Dennis Kim  ‧  Althea Davis  ‧  Jeanie  ‧  Cinnamon  ‧  Mrs. Rostenkowski  ‧  Wyatt  ‧  Claire  ‧  Kurt  ‧  Eric Gablehauser  ‧  Dave Gibbs  ‧  Dimitri  ‧  Alfred Hofstadter   ‧  Meemaw  ‧  Susan  ‧  Randall  ‧  Bert Kibbler  ‧  President Siebert  ‧  Janine Davis  ‧  Colonel Richard Williams  ‧  Halley Wolowitz  ‧  Neil Michael Wolowitz  ‧  Denise  ‧ George Cooper Jr.  ‧  Larry Fowler
Cast Regulars Johnny Galecki  ‧  Jim Parsons  ‧  Kaley Cuoco  ‧  Simon Helberg  ‧  Kunal Nayyar  ‧  Mayim Bialik  ‧  Melissa Rauch  ‧  Kevin Sussman  ‧  Laura Spencer  ‧  Sara Gilbert  ‧ 
Recurring/Minor Christine Baranski  ‧  Aarti Mann  ‧  John Ross Bowie  ‧  Casey Sander  ‧  Stephen Merchant  ‧  Sara Rue  ‧  Kara Luiz  ‧  Brian Thomas Smith  ‧  Margo Harshman  ‧  Alessandra Torresani  ‧  Matt Bennett  ‧  Keith Carradine  ‧  Laurie Metcalf  ‧  Judd Hirsch  ‧  Carol Ann Susi  ‧  Meagen Fay  ‧  Brian George  ‧  Alice Amter  ‧  Courtney Henggeler  ‧  June Squibb  ‧  Katey Sagal  ‧  Jack McBrayer  ‧  Dean Norris  ‧  Brian Posehn  ‧  Mark Harelik  ‧  Joshua Malina  ‧  Brian Patrick Wade  ‧  Kate Micucci  ‧  Regina King  ‧  Jerry O'Connell
As Selves Wil Wheaton  ‧  Mike Massimino  ‧  Stephen Hawking  ‧  Katee Sackhoff  ‧ Steve Wozniak  ‧ Buzz Aldrin  ‧ Summer Glau  ‧ James Earl Jones  ‧ Carrie Fisher  ‧ Brent Spiner  ‧ Howie Mandel  ‧ Bill Nye  ‧ George Smoot  ‧ George Takei  ‧ LeVar Burton  ‧ Neil deGrasse Tyson  ‧ Brian Greene  ‧ Charlie Sheen  ‧ Stan Lee  ‧ Adam West
Crew Writers Chuck Lorre * (Creator)  ‧  Bill Prady * (Creator)  ‧  Steven Molaro *  ‧  Steve Holland *  ‧  Maria Ferrari *  ‧  Jim Reynolds *  ‧  Eric Kaplan *  ‧  Anthony Del Broccolo  ‧  Lee Aronsohn *  ‧  Dave Goetsch *  ‧  Tara Hernandez  ‧  Richard Rosenstock *
Directors Mark Cendrowski  ‧  Peter Chakos * (mainly as Editor)  ‧  Anthony Rich  ‧  James Burrows
Others
Science consultant : David Saltzberg Director of photography : Steven V. Silver
Costume designer : Mary T. Quigley * Unit production manager : Kelly-Anne Lee *
Theme composer / performer : Barenaked Ladies Chuck Lorre Productions
also as Producer The Big Bang Theory : Full cast & crew on IMDb