In the Young Sheldon episode "Cape Canaveral, Schrödinger's Cat, and Cyndi Lauper's Hair" it is mentioned by Mary Cooper that her siblings are Charlene and Edward. It is possible that Charlene later becomes Carl.
- Father: Pop-pop
- Mother: Meemaw
- Sister: Mary Cooper
- Brother: Edward
- Brother-in-law: George Cooper Sr.
- Nephews: Sheldon Cooper, George Cooper Jr.
- Niece: Missy Cooper