Brenda works at the bowling alley that Meemaw frequently goes to.
She constantly yells at and bosses her husband Herschel. As George is bossed around by his wife Mary, this leads to the two men both bond over how they are often dominated by their wives.
Brenda is rather shrewish and bad-tempered. She and Mary clash often and seems to have no redeeming qualities.
Despite clashing with Mary, there are two moments where they sympathize with each other. In "A Party Invitation, Football Grapes and an Earth Chicken", Brenda and Mary acknowledge that they both have difficulty dealing with children that are considered strange and unpopular, Mary with Sheldon, and Brenda with Billy. The second time is in "A Secret Letter and a Lowly Disc of Processed Meat", where she catches Mary outside sulking and begins to mock her. But when she sees that Mary is genuinely distressed, she apologizes and invites Mary over for drinks where they talk about how they worry about their children’s futures.
- It is mentioned that she drinks a lot. In "An Academic Crime and a More Romantic Taco Bell", she organizes a meeting between all the baseball mothers, but it's really just an excuse to get drunk.